Affiliation:
1. State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116023 P. R. China
2. School of Chemical Engineering Dalian University of Technology Panjin 124221 P. R. China
3. National Institute of Advanced Industrial Science and Technology Tsukuba 305-8569 Japan
Abstract
AbstractTransition‐metal‐catalyzed acceptorless dehydrogenative coupling (ADC) has emerged as a sustainable synthetic strategy for the construction of N‐heteroaromatics. Herein, a series of water‐soluble amidato Ru catalysts were designed, synthesized, and utilized in the selective synthesis of 2‐substituted benzimidazoles from the aromatic diamines and primary alcohols, as well as 2‐substituted quinolines from the substituted 2‐aminobenzyl alcohols and acetophenones via the ADC strategy in water. Catalyst 1 d bearing a strong electron‐donating hydroxyl group on the ligand exhibited the best catalytic activity. The catalytic system demonstrated remarkable efficiency and versatility, allowing for the application of over 40 substrates in two ADC reactions with good to high yields. Based on control experiments and density functional theory (DFT) calculations, a plausible mechanism was proposed, highlighting the significant role of functionalized amidato Ru complexes in catalyzing alcohol dehydrogenation via an outer‐sphere pathway.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Liaoning Revitalization Talents Program
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis
Cited by
3 articles.
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