Cu-catalyzed convenient synthesis of 2-trifluoromethyl benzimidazoles <i>via</i> cyclization of <i>o</i>-phenylenediamines with hexafluoroacetylacetone-Reference-Cited by-同舟云学术

Cu-catalyzed convenient synthesis of 2-trifluoromethyl benzimidazoles via cyclization of o-phenylenediamines with hexafluoroacetylacetone

Published:2023 Issue:48 Volume:21 Page:9542-9546
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chen Xia¹²,Zhou Xiao-Yu²^ORCID,Liu Hai-Long²,Zhang Sheng¹^ORCID,Bao Ming¹^ORCID

Affiliation:

1. State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China

2. School of Chemistry and Materials Engineering, Liupanshui Normal University, Liupanshui, 553004, China

Abstract

An efficient and convenient method is developed for the synthesis of 2-trifluoromethyl benzimidazoles using Cu2O as the pre-catalyst. The reaction mechanism involving a seven-membered cyclic diimine intermediate was thoroughly investigated.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guizhou Province

Department of Education of Guizhou Province

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01702H

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