Normal fat intake with high MUFA content and an appropriate SFA/MUFA/PUFA ratio improved the health of rats

Author:

Zhou Yuhao1,Yang Ligang1,Chu Chu1,Chen Shiqing2,Yue Danwei2,Hao Yoong Jun3,Sun Guiju1,Xia Hui1

Affiliation:

1. Key Laboratory of Environmental Medicine and Engineering of Ministry of Education Department of Nutrition and Food Hygiene, School of Public Health, Southeast University Nanjing China

2. Palm Oil Research and Technical Service Institute of Malaysian Palm Oil Board Shanghai PR China

3. Malaysian Palm Oil Board, 6 Persiaran Institusi BandarBaru Bangi Kajang Selangor Malaysia

Abstract

AbstractThe quantity and quality of dietary fats have a significant impact on human health. This study aimed to investigate the effects of different cooking oils (olive oil (OO), soybean oil (SO), and blended oil (BO)) on growth, glucolipid metabolism, inflammation, and oxidative stress of rats fed normal and high‐fat diets. The results showed that the OO‐fed group had lower concentrations of serum triglyceride (TG), low‐density lipoprotein cholesterol (LDL‐C), malondialdehyde (MDA), oxidized LDL‐C (ox‐LDL‐C), and serum total cholesterol (TC) than the normal‐fat SO‐fed group, and rats in the BO‐fed group had lower values of serum interleukin‐6 (IL‐6), high‐sensitivity C‐reactive protein (hs‐CRP), tumor necrosis factor (TNF‐α), and nonesterified fatty acids (NEFA) than the normal‐fat SO‐fed groups. However, higher serum glutathione peroxidase (GSH‐Px) activity was observed in the OO‐fed group, while those fed with BO had higher serum superoxide dismutase (SOD) and GSH‐Px activities. Generally, most health‐beneficial fatty acid profiles have a high content of monounsaturated fatty acids (MUFAs), an appropriate saturated fatty acid (SFA)/MUFA/poly unsaturated fatty acid (PUFA) ratio, and a low n‐6/n‐3 PUFA ratio, while diets contained a high content of fat is detrimental to health.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Wiley

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