Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration ofin vitroliver-kidney microfluidic data and pharmacokinetic-system biology models-Reference-Cited by-同舟云学术

Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration ofin vitroliver-kidney microfluidic data and pharmacokinetic-system biology models

Published:2015-07-07 Issue:2 Volume:36 Page:330-339
ISSN:0260-437X
Container-title:Journal of Applied Toxicology
language:en
Short-container-title:J. Appl. Toxicol.

Author:

Leclerc Eric¹,Hamon Jeremy¹,Bois Frederic Yves¹²³

Affiliation:

1. CNRS UMR 7338, Laboratoire de Biomécanique et Bio ingénierie; Université de Technologie de Compiègne; France

2. Chaire de Toxicologie Prédictive; Université de Technologie de Compiègne; France

3. Institut National de l'Environnement Industriel et des Risques (INERIS); Unité Modèles pour l'Écotoxicologie et la Toxicologie; Parc ALATA, BP2 60550 Verneuil en Halatte France

Funder

UTC foundation

Publisher

Wiley

Subject

Toxicology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jat.3191/fullpdf

Reference58 articles.

1. Comparative pharmacokinetics of oral and intravenous Ifosfamide /Mesna/Methylene blue therapy;Aechlimann;D.M.D.,1998

2. Renal tubule metabolism of ifosfamide to nephrotoxic chloroacetaldehyde: pharmacokinetic modelling for estimation of intracellular levels;Aleksa;J. Lab. Clin. Med.,2004

3. Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study;Aschauer;Toxicol. In Vitro,2014