Structural analysis of random transgene integration in CHO manufacturing cell lines by targeted sequencing-Reference-Cited by-同舟云学术

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Structural analysis of random transgene integration in CHO manufacturing cell lines by targeted sequencing

Published:2022-01-19 Issue:3 Volume:119 Page:868-880
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotech & Bioengineering

Author:

Stadermann Anna¹,Gamer Martin²,Fieder Jürgen¹,Lindner Benjamin¹^ORCID,Fehrmann Steffen³,Schmidt Moritz¹,Schulz Patrick¹,Gorr Ingo H.⁴^ORCID

Affiliation:

1. Bioprocess Development Biologicals, Cell Line Development Boehringer Ingelheim GmbH & Co. KG Biberach Germany

2. R&D Project Management NBEs Boehringer Ingelheim GmbH & Co. KG Biberach Germany

3. Genedata AG, Selector BU Basel Switzerland

4. Analytical Development Biologicals Boehringer Ingelheim GmbH & Co. KG Biberach Germany

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.28012

Reference45 articles.

1. Analytical assessment of clonal derivation of eukaryotic/CHO cell populations

2. Enhanced CHO Clone Screening: Application of Targeted Locus Amplification and Next‐Generation Sequencing Technologies for Cell Line Development

3. Recurring genomic structural variation leads to clonal instability and loss of productivity

4. Trimmomatic: a flexible trimmer for Illumina sequence data

5. Chinese hamster genome sequenced from sorted chromosomes

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1. Ubiquitous chromatin opening element enhance Darbepoetin alfa expression in CHO DG44 cell line;Biochemical Engineering Journal;2024-11

2. Evaluation of two transposases for improving expression of recombinant proteins in Chinese hamster ovary cell stable pools by co‐transfection and supertransfection approaches;Biotechnology Progress;2024-07-17

3. Droplet digital PCR: A comprehensive tool for genetic analysis and prediction of bispecific antibody assembly during cell line development;New Biotechnology;2023-12

4. Genomic features of recombinant CHO clones arising from transposon-based and randomized integration;Journal of Biotechnology;2023-08

5. Deciphering integration loci of CHO manufacturing cell lines using long read nanopore sequencing;New Biotechnology;2023-07

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