Recurring genomic structural variation leads to clonal instability and loss of productivity

Author:

Bandyopadhyay Arpan A.1,O’Brien Sofie A.1,Zhao Liang12ORCID,Fu Hsu-Yuan13,Vishwanathan Nandita14,Hu Wei-Shou1ORCID

Affiliation:

1. Department of Chemical Engineering and Materials Science; University of Minnesota; Minneapolis Minnesota

2. Present address: East China University of Science and Technology; Shanghai China

3. Present address: MycoMagic Co. Ltd; New Taipei City Taiwan

4. Present address: Merck Serono; Corsier-sur-Vevey Switzerland

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference56 articles.

1. A framework to quantify karyotype variation associated with CHO cell line instability at a single-cell level;Baik;Biotechnology and Bioengineering,2017

2. Determination of Chinese hamster ovary cell line stability and recombinant antibody expression during long-term culture;Bailey;Biotechnology and Bioengineering,2012

3. Genomics and systems biotechnology in biopharmaceutical processing;Bandyopadhyay;Chemical Engineering Progress,2014

4. Advancement in bioprocess technology: Parallels between microbial natural products and cell culture biologics;Bandyopadhyay;Journal of Industrial Microbiology and Biotechnology,2017

5. Stability of protein production from recombinant mammalian cells;Barnes;Biotechnology and Bioengineering,2003

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