High IL2RA/CD25 expression is a prognostic stem cell biomarker for pediatric acute myeloid leukemia without a core‐binding factor

Author:

Aoki Takahiro1ORCID,Shiba Norio2,Tsujimoto Shinichi2ORCID,Yamato Genki3ORCID,Hara Yusuke3,Kato Shota4,Yoshida Kenichi5,Ogawa Seishi678,Hayashi Yasuhide9,Iwamoto Shotaro10,Taki Tomohiko11,Shimada Akira12,Iijima‐Yamashita Yuka13,Horibe Keizo13,Tawa Akio14,Taga Takashi15ORCID,Adachi Souichi16,Tomizawa Daisuke17ORCID

Affiliation:

1. Department of Pediatrics Graduate School of Medicine Chiba University Chiba Japan

2. Department of Pediatrics Yokohama City University Graduate School of Medicine Yokohama Japan

3. Department of Pediatrics Gunma University Graduate School of Medicine Maebashi Japan

4. Department of Pediatrics Graduate School of Medicine The University of Tokyo Tokyo Japan

5. Division of Cancer Evolution National Cancer Center Research Institute Tokyo Japan

6. Department of Pathology and Tumor Biology Graduate School of Medicine Kyoto University Kyoto Japan

7. Institute for the Advanced Study of Human Biology (WPI‐ASHBi) Kyoto University Kyoto Japan

8. Department of Medicine Center for Hematology and Regenerative Medicine Karolinska Institute Stockholm Sweden

9. Institute of Physiology and Medicine Jobu University Takasaki Japan

10. Department of Pediatrics Mie University Tsu Japan

11. Department of Medical Technology Kyorin University Faculty of Health Sciences Mitaka Japan

12. Department of Pediatrics Jichi Medical University Shimotsuke Japan

13. Clinical Research Center NHO Nagoya Medical Center Nagoya Japan

14. Higashiosaka Aramoto Heiwa Clinic Higashiosaka Japan

15. Department of Pediatrics Shiga University of Medical Science Shiga Japan

16. Department of Human Health Science Kyoto University Kyoto Japan

17. Division of Leukemia and Lymphoma Children's Cancer Center National Center for Child Health and Development Tokyo Japan

Abstract

AbstractCD25 is an aberrant marker expressed on the leukemic stem cell (LSC) surface and an immunotherapy target in acute myeloid leukemia (AML). However, the clinical prevalence and significance of CD25 expression in pediatric AML are unknown. High IL2RA/CD25 expression in pediatric AML showed a stem cell‐like phenotype, and elevated CD25 expression was associated with lower overall survival (p < .001) and event‐free survival (p < .001) in the Japanese Pediatric Leukemia/Lymphoma Study Group AML‐05 study. This finding was reproduced in AML without a core‐binding factor in the Children's Oncology Group study cohort. High CD25 expression has prognostic significance in pediatric AML.

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

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