Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells

Author:

Saito Yoriko1,Kitamura Hiroshi2,Hijikata Atsushi2,Tomizawa-Murasawa Mariko1,Tanaka Satoshi3,Takagi Shinsuke1,Uchida Naoyuki4,Suzuki Nahoko1,Sone Akiko1,Najima Yuho1,Ozawa Hidetoshi1,Wake Atsushi4,Taniguchi Shuichi4,Shultz Leonard D.5,Ohara Osamu2,Ishikawa Fumihiko1

Affiliation:

1. Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology, Yokohama, 230-0045 Japan.

2. Laboratory for Immunogenomics, RIKEN Research Center for Allergy and Immunology, Yokohama, 230-0045 Japan.

3. Nippon Becton Dickinson Company, Tokyo, 107-0052 Japan.

4. Department of Hematology, Toranomon Hospital, Tokyo, 105-8470 Japan.

5. The Jackson Laboratory, Bar Harbor, ME 04609, USA.

Abstract

CD32 and CD25, molecules specifically found in human leukemia stem cells, are promising targets for therapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

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2. Prognostic Index for Adult Patients With Acute Myeloid Leukemia in First Relapse

3. Medical Research Council Adult Leukemia Working Party, The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): Analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial.;Grimwade D.;Blood,2001

4. The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 Trial

5. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

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