OCT 1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil
Author:
Affiliation:
1. Institute for Clinical PharmacologyUniversity Medical Center GöttingenGeorg‐August University Göttingen Germany
2. Institut für PharmakologieUniversitätsmedizinErnst‐Moritz‐Arndt‐Universität Greifswald Greifswald Germany
Funder
Deutsche Forschungsgemeinschaft
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.1128
Reference48 articles.
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2. In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.
3. The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism-a panel study.
4. Comparison of chloroguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans*
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