In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.-Reference-Cited by-同舟云学术

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In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.

Published:1990-08 Issue:2 Volume:30 Page:287-291
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:British Journal of Clinical Pharmacology

Author:

Helsby NA,Ward SA,Howells RE,Breckenridge AM

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1365-2125.1990.tb03777.x/fullpdf

Reference30 articles.

1. Interactions between nutritional factors and drug biotransformation in man;Alvares;Proc. Natl. Acad. Sci. USA,1976

2. Metabolism of chlorguanide, a unique mixed function oxidase substrate;Armstrong;Diss. Abstr.,1973

3. Cyclisation and N-dealkylation of chlorguanide by rabbit and rat hepatic microsomes;Armstrong;Toxicol. appl. Pharmac.,1974

4. Substrate specificity of the form of cytochrome P450 catalysing the 4-hydroxylation of debrisoquine in man;Boobis;Mol. Pharmac.,1983

5. A metabolite of ‘Paludrine’ with high antimalarial activity;Carrington;Nature,1951

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