New method for the simultaneous estimation of intrinsic hepatic clearance and protein binding by matrix inhibition-Reference-Cited by-同舟云学术

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New method for the simultaneous estimation of intrinsic hepatic clearance and protein binding by matrix inhibition

Published:2007 Issue:1 Volume:29 Page:7-16
ISSN:0142-2782
Container-title:Biopharmaceutics & Drug Disposition
language:en
Short-container-title:Biopharm. Drug Dispos.

Author:

Uchimura Takahide,Kato Motohiro,Tachibana Tatsuhiko,Arai Shinichi,Nabuchi Yoshiaki,Saito Kimitoshi,Kinoshita Haruki

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference23 articles.

1. A physiological approach to hepatic drug clearance

2. Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

3. Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches

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1. An update on the importance of plasma protein binding in drug discovery and development;Expert Opinion on Drug Discovery;2021-08-17

2. In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals;Chemical Research in Toxicology;2021-01-12

3. Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model;Chemical Research in Toxicology;2020-11-17

4. Plasma, liver, and kidney exposures in rats after oral doses of industrial chemicals predicted using physiologically based pharmacokinetic models: A case study of perﬂuorooctane sulfonic acid;The Journal of Toxicological Sciences;2020

5. Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies;Journal of Pharmaceutical Sciences;2013-08

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