Plasma, liver, and kidney exposures in rats after oral doses of industrial chemicals predicted using physiologically based pharmacokinetic models: A case study of perfluorooctane sulfonic acid
Author:
Affiliation:
1. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/45/12/45_763/_pdf
Reference18 articles.
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2. Benskin, J.P., De Silva, A.O., Martin, L.J., Arsenault, G., McCrindle, R., Riddell, N., Mabury, S.A. and Martin, J.W. (2009a): Disposition of perfluorinated acid isomers in Sprague-Dawley rats; part 1: single dose. Environ. Toxicol. Chem., 28, 542-554.
3. Benskin, J.P., Holt, A. and Martin, J.W. (2009b): Isomer-specific biotransformation rates of a perfluorooctane sulfonate (PFOS)-precursor by cytochrome P450 isozymes and human liver microsomes. Environ. Sci. Technol., 43, 8566-8572.
4. Brown, R.P., Delp, M.D., Lindstedt, S.L., Rhomberg, L.R. and Beliles, R.P. (1997): Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health, 13, 407-484.
5. Davies, B. and Morris, T. (1993): Physiological parameters in laboratory animals and humans. Pharm. Res., 10, 1093-1095.
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