An update on the importance of plasma protein binding in drug discovery and development
Author:
Affiliation:
1. Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, CT, US
Funder
not funded
Publisher
Informa UK Limited
Subject
Drug Discovery
Link
https://www.tandfonline.com/doi/pdf/10.1080/17460441.2021.1961741
Reference94 articles.
1. The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery
2. Rational Use of Plasma Protein and Tissue Binding Data in Drug Design
3. Changes in plasma protein binding have little clinical relevance
4. Ontogeny of plasma proteins, albumin and binding of diazepam, cyclosporine, and deltamethrin
5. What is the True Clinical Significance of Plasma Protein Binding Displacement Interactions?
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