Evaluation of the CYP3A and CYP2B6 Drug‐Drug Interaction Potential of Lemborexant-Reference-Cited by-同舟云学术

Evaluation of the CYP3A and CYP2B6 Drug‐Drug Interaction Potential of Lemborexant

Published:2021-01-17 Issue:6 Volume:10 Page:681-690
ISSN:2160-763X
Container-title:Clinical Pharmacology in Drug Development
language:en
Short-container-title:Clinical Pharmacology in Drug Development

Author:

Landry Ishani¹,Aluri Jagadeesh¹,Nakai Kenya²,Hall Nancy¹,Miyajima Yukiko²,Ueno Takashi²,Dayal Satish³,Filippov Gleb¹,Lalovic Bojan¹,Moline Margaret¹,Reyderman Larisa¹

Affiliation:

1. Eisai Inc. Woodcliff Lake New Jersey USA

2. Eisai Co., Ltd Tokyo Japan

3. Eisai Ltd. Hatfield UK

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.915

Reference9 articles.

1. Discovery of (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist

2. Comparison of Lemborexant With Placebo and Zolpidem Tartrate Extended Release for the Treatment of Older Adults With Insomnia Disorder

3. Long-term efficacy and tolerability of lemborexant compared with placebo in adults with insomnia disorder: results from the phase 3 randomized clinical trial SUNRISE 2

4. Pharmacokinetics, Pharmacodynamics, and Safety of the Dual Orexin Receptor Antagonist Lemborexant: Findings From Single‐Dose and Multiple‐Ascending‐Dose Phase 1 Studies in Healthy Adults

5. Population Pharmacokinetics and Exposure‐Response Analyses for the Most Frequent Adverse Events Following Treatment With Lemborexant, an Orexin Receptor Antagonist, in Subjects With Insomnia Disorder

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