Pharmacokinetics, Pharmacodynamics, and Safety of the Dual Orexin Receptor Antagonist Lemborexant: Findings From Single‐Dose and Multiple‐Ascending‐Dose Phase 1 Studies in Healthy Adults-Reference-Cited by-同舟云学术

Pharmacokinetics, Pharmacodynamics, and Safety of the Dual Orexin Receptor Antagonist Lemborexant: Findings From Single‐Dose and Multiple‐Ascending‐Dose Phase 1 Studies in Healthy Adults

Published:2020-05-28 Issue:2 Volume:10 Page:153-165
ISSN:2160-763X
Container-title:Clinical Pharmacology in Drug Development
language:en
Short-container-title:Clinical Pharmacology in Drug Development

Author:

Landry Ishani¹,Nakai Kenya²,Ferry Jim¹,Aluri Jagadeesh¹,Hall Nancy¹,Lalovic Bojan¹,Moline Margaret L.¹

Affiliation:

1. Eisai Inc Woodcliff Lake New Jersey USA

2. Eisai Co, Ltd, Koishikawa Tokyo Japan

Funder

Eisai Inc. Medical

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.817

Reference26 articles.

1. The roles of orexins in sleep/wake regulation

2. The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions

3. Orexin Receptors: Pharmacology and Therapeutic Opportunities

4. Orexin deficiency and narcolepsy

5. Increased plasma orexin-A levels in patients with insomnia disorder are not associated with prepro-orexin or orexin receptor gene polymorphisms

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