Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOquin® given intravesically-Reference-Cited by-同舟云学术

Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOquin® given intravesically

Published:2008-02-28 Issue:4 Volume:22 Page:462-470
ISSN:0951-4198
Container-title:Rapid Communications in Mass Spectrometry
language:en
Short-container-title:Rapid Commun. Mass Spectrom.

Author:

Vainchtein Liia D.,Rosing Hilde,Mirejovsky Dorla,Huynh Van,Lenaz Luigi,Schellens Jan H. M.,Beijnen Jos H.

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference20 articles.

1. EO9: A novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

2. Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs

3. Phase I pharmacokinetics and limited sampling strategies for the bioreductive alkylating drug EO9

4. A systematic study on the chemical stability of the novel indoloquinone antitumour agent EO9

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1. Naphthoquinones and Anthraquinones: Chemical, Analytical, and Biological Overview;Encyclopedia of Analytical Chemistry;2014-09-22

2. Liquid Chromatography-Mass Spectrometric Multiple Reaction Monitoring-based Strategies for Expanding Targeted Profiling towards Quantitative Metabolomics;Current Drug Metabolism;2012-10-01

3. Phase 2 Study of Adjuvant Intravesical Instillations of Apaziquone for High Risk Nonmuscle Invasive Bladder Cancer;Journal of Urology;2012-04

4. The chemical and biological activities of quinones: overview and implications in analytical detection;Phytochemistry Reviews;2011-04-20

5. Increasing high-throughput Discovery bioanalysis using automated selected reaction monitoring compound optimization, ultra-high-pressure liquid chromatography, and single-step sample preparation workflows;Rapid Communications in Mass Spectrometry;2009-10-08