EO9: A novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

Author:

Hendriks H.R.,Pizao P.E.,Berger D.P.,Kooistra K.L.,Bibby M.C.,Boven E.,Dreef-van der Meulen H.C.,Henrar R.E.C.,Fiebig H.H.,Double J.A.,Hornstra H.W.,Pinedo H.M.,Workman P.,Schwartsmann G.

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference40 articles.

1. Mitomycin analogs I. Indoloquinones as (potential) bisalkylating agents;Oostveen;Tetrahedron,1987

2. Preclinical antitumor profile of E09, a novel bioreductive alkylating indoloquinone derivative;Winograd,1989

3. DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs?;Workman;Br J Cancer,1989

4. The role of NAD(P)H: quinone reductase (EC1.6.99.2,DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumour agent E09;Walton;Cancer Commun,1991

5. Bioreductive activation of indoloquinone E09: involvement of DT-diaphorase and DNA crosslinking;Bailey;Ann Oncol,1992

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