Effects of protein engineering and rational mutagenesis on crystal lattice of single chain antibody fragments
Author:
Affiliation:
1. School of Chemistry & Biochemistry; Georgia Institute of Technology; Atlanta Georgia 30332-0400
2. McKetta Department of Chemical Engineering; University of Texas at Austin, MC0400, 1 University Station; Austin Texas 78712
Funder
National Institutes of Health
NIH
US Department of Education Graduate Assistance in Areas of National Need
Welch Foundation
Publisher
Wiley
Subject
Molecular Biology,Biochemistry,Structural Biology
Reference39 articles.
1. Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data;Price;Nat Biotechnol,2009
2. The protein as a variable in protein crystallization;Dale;J Struct Biol,2003
3. Studies on engineering crystallizability by mutation of surface residues of human thymidylate synthase;Mcelroy;J Cryst Growth,1992
4. Engineering soluble proteins for structural genomics;Pedelacq;Nat Biotechnol,2002
5. In situ proteolysis to generate crystals for structure determination: an update;Wernimont;PLoS One,2009
Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. MEnTaT: A machine-learning approach for the identification of mutations to increase protein stability;Proceedings of the National Academy of Sciences;2023-12
2. Strategies to improve scFvs as crystallization chaperones suggested by analysis of a complex with the human PHD-bromodomain SP140;2019-09-13
3. Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry;Nature Communications;2019-01-03
4. De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide;Scientific Reports;2017-08-31
5. Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization;Acta Crystallographica Section D Biological Crystallography;2015-03-27
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3