Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-07851-1.pdf
Reference50 articles.
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2. Brandenberg, O. F., Magnus, C., Regoes, R. R. & Trkola, A. The HIV-1 entry process: a stoichiometric view. Trends Microbiol. 23, 763–774 (2015).
3. Lu, L., Yu, F., Cai, L., Debnath, A. K. & Jiang, S. Development of small-molecule HIV entry inhibitors specifically targeting gp120 or gp41. Curr. Top. Med. Chem. 16, 1074–1090 (2016).
4. Meanwell, N. A. et al. Inhibitors of HIV-1 attachment: the discovery and development of Temsavir and its Prodrug Fostemsavir. J. Med. Chem. 61, 62–80 (2018).
5. Kirchmair, J. et al. Predicting drug metabolism: experiment and/or computation? Nat. Rev. Drug Discov. 14, 387–404 (2015).
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