Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier

Author:

Tran Thuy Thanh,Gales Tracy,Maleeff Beverly,Aldinger Tanya,Polli Joseph W.,Ayrton Andrew,Ellens Harma,Bentz Joe,Mittal Aditya

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference15 articles.

1. Transport and diffusion across cell membranes;Stein,1986

2. A biophysical model of passive and polarized active transport processes in Caco-2 cells: Approaches to uncoupling apical and basolateral membrane events in the intact cell;Ho;J Pharm Sci,1995

3. Quantitative approaches to delineate passive transport mechanisms in cell culture monolayers;Ho;Transport Proc Pharm Syst,2000

4. Role of P-glycoprotein-mediated secretion in absorptive drug permeability: An approach using passive membrane permeability and affinity to P-glycoprotein;Doppenschmitt;J Pharm Sci,1999

5. In vitro trans-monolayer permeability calculations: Often forgotten assumptions;Youdim;Drug Disc Today,2003

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