Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses-Reference-Cited by-同舟云学术

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Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses

Published:2018-04-20 Issue:8 Volume:10 Page:1237-1243
ISSN:1942-7603
Container-title:Drug Testing and Analysis
language:en
Short-container-title:Drug Test Anal

Author:

Knych Heather K.¹²^ORCID,Seminoff Kelsey¹,McKemie Dan S.¹

Affiliation:

1. K.L. Maddy Equine Analytical Chemistry Laboratory, School of Veterinary Medicine; University of California; Davis California

2. Department of Veterinary Molecular Biosciences, School of Veterinary Medicine; University of California; Davis California

Funder

California Horse Racing Board

Publisher

Wiley

Subject

Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/dta.2378/fullpdf

Reference16 articles.

1. Nonsteroidal anti-inflammatory drug use in horses;Knych;Vet Clin North Am Equine Pract,2017

2. Prospective, randomized, masked, placebo-controlled multisite clinical study of grapiprant, an EP4 prostaglandin receptor antagonist (PRA) in dogs with osteoarthritis;Rausch-Derra;J Vet Intern Med,2016

3. Effects of the selective EP4 antagonist, CJ-023,423 on chronic inflammation and bone destruction in rat adjuvant-induced arthritis;Okumura;J Pharm Pharmacol,2008

4. A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism;Boyd;Bioorg Med Chem Lett,2011

5. M. A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models;Chen;Br J Pharmacol,2010

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