A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism-Reference-Cited by-同舟云学术

A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism

Published:2011-01 Issue:1 Volume:21 Page:484-487
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Boyd Michael J.,Berthelette Carl,Chiasson Jean-François,Clark Patsy,Colucci John,Denis Danielle,Han Yongxin,Lévesque Jean-Francois,Mathieu Marie-Claude,Stocco Rino,Therien Alex,Rowland Steve,Wrona Mark,Xu Daigen

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo.

2. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

3. Role of PGE2 and EP Receptors in the Pathogenesis of Rheumatoid Arthritis and as a Novel Therapeutic Strategy

4. The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

5. MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis

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