An Algorithm for Evaluating Potential Tissue Drug Distribution in Toxicology Studies from Readily Available Pharmacokinetic Parameters-Reference-Cited by-同舟云学术

An Algorithm for Evaluating Potential Tissue Drug Distribution in Toxicology Studies from Readily Available Pharmacokinetic Parameters

Published:2013-10 Issue:10 Volume:102 Page:3816-3829
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Poulin Patrick,Dambach Donna M.,Hartley Dylan H.,Ford Kevin,Theil Frank-Peter,Harstad Eric,Halladay Jason,Choo Edna,Boggs Jason,Liederer Bianca M.,Dean Brian,Diaz Dolores

Funder

Genentech

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference31 articles.

1. Pharmacokinetic drivers of toxicity for basic molecules: Strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor;Diaz;Toxicol Appl Pharmacol,2013

2. Insight into tissue unbound concentration: Utility in drug discovery and development;Mariappan;Curr Drug Metab,2013

3. A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically based pharmacokinetic models in drug discovery;Poulin;J Pharm Sci,2000

4. Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods;Poulin;J Pharm Sci,2009

5. A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human;Poulin;Toxicol Appl Pharmacol,2011

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