Pharmacokinetic drivers of toxicity for basic molecules: Strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor-Reference-Cited by-同舟云学术

Pharmacokinetic drivers of toxicity for basic molecules: Strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor

Published:2013-01 Issue:1 Volume:266 Page:86-94
ISSN:0041-008X
Container-title:Toxicology and Applied Pharmacology
language:en
Short-container-title:Toxicology and Applied Pharmacology

Author:

Diaz Dolores,Ford Kevin A.,Hartley Dylan P.,Harstad Eric B.,Cain Gary R.,Achilles-Poon Kirsten,Nguyen Trung,Peng Jing,Zheng Zhong,Merchant Mark,Sutherlin Daniel P.,Gaudino John J.,Kaus Robert,Lewin-Koh Sock C.,Choo Edna F.,Liederer Bianca M.,Dambach Donna M.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference32 articles.

1. Mitochondrial pH monitored by a new engineered green fluorescent protein mutant;Abad;J. Biol. Chem.,2004

2. 1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pKa;Arbuckle;Bioorg. Med. Chem. Lett.,2011

3. Volume of distribution at steady state for a linear pharmacokinetic system with peripheral elimination;Berezhkovskiy;J. Pharm. Sci.,2004

4. Prediction of V(ss) from in vitro tissue-binding studies;Berry;Drug Metab. Dispos.,2010

5. Drug development of MET inhibitors: targeting oncogene addiction and expedience;Comoglio;Nat. Rev.,2008

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Safety and hematological toxicities of PARP inhibitors in patients with cancer: a systematic review of randomized controlled trials and a pharmacovigilance analysis;Expert Review of Anticancer Therapy;2024-05-23

2. Synthesis and Chemoinformatic Analysis of Fluorinated Piperidines as 3D Fragments for Fragment-Based Drug Discovery;The Journal of Organic Chemistry;2024-03-07

3. Complexity‐to‐Diversity and Pseudo‐Natural Product Strategies as Powerful Platforms for Deciphering Next‐Generation Therapeutics;ChemMedChem;2023-06-12

4. Physicochemical Properties;The Handbook of Medicinal Chemistry;2023-02-03

5. Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation;J MED CHEM;2022