Comprehensive Fragment Screening of the SARS‐CoV‐2 Proteome Explores Novel Chemical Space for Drug Development-Reference-Cited by-同舟云学术

Comprehensive Fragment Screening of the SARS‐CoV‐2 Proteome Explores Novel Chemical Space for Drug Development

Published:2022-10-13 Issue:46 Volume:61 Page:
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew Chem Int Ed

Author:

Berg Hannes¹²^ORCID,Wirtz Martin Maria A.¹²^ORCID,Altincekic Nadide¹²^ORCID,Alshamleh Islam¹²^ORCID,Kaur Bains Jasleen¹²,Blechar Julius¹,Ceylan Betül¹²,de Jesus Vanessa¹²,Dhamotharan Karthikeyan²³^ORCID,Fuks Christin¹,Gande Santosh L.¹²,Hargittay Bruno¹²,Hohmann Katharina F.¹²,Hutchison Marie T.¹²,Marianne Korn Sophie²³^ORCID,Krishnathas Robin¹²,Kutz Felicitas¹²,Linhard Verena¹²,Matzel Tobias¹²,Meiser Nathalie¹,Niesteruk Anna¹²,Pyper Dennis J.¹²,Schulte Linda¹²^ORCID,Trucks Sven¹,Azzaoui Kamal⁴,Blommers Marcel J. J.⁴,Gadiya Yojana⁵⁶,Karki Reagon⁵⁶,Zaliani Andrea⁵⁶,Gribbon Philip⁵⁶,da Silva Almeida Marcius⁷⁶^ORCID,Dinis Anobom Cristiane⁸⁹,Bula Anna L.¹⁰,Bütikofer Matthias¹¹,Putinhon Caruso Ícaro⁷¹²,Caterina Felli Isabella¹³¹⁴^ORCID,Da Poian Andrea T.⁷,Cardoso de Amorim Gisele⁷¹⁵,Fourkiotis Nikolaos K.¹⁶^ORCID,Gallo Angelo¹⁶¹⁷^ORCID,Ghosh Dhiman¹¹,Gomes‐Neto Francisco⁸¹⁸,Gorbatyuk Oksana¹⁹,Hao Bing¹⁹,Kurauskas Vilius²⁰,Lecoq Lauriane²¹,Li Yunfeng¹⁹,Cunha Mebus‐Antunes Nathane⁷,Mompeán Miguel²²,Cristtina Neves‐Martins Thais⁷,Ninot‐Pedrosa Martí²¹^ORCID,Pinheiro Anderson S.⁹,Pontoriero Letizia¹³¹⁴^ORCID,Pustovalova Yulia¹⁹,Riek Roland¹¹,Robertson Angus J.²³,Jose Abi Saad Marie²⁴,Treviño Miguel Á.²²^ORCID,Tsika Aikaterini C.¹⁶^ORCID,Almeida Fabio C. L.⁷⁸^ORCID,Bax Ad²³^ORCID,Henzler‐Wildman Katherine²⁰^ORCID,Hoch Jeffrey C.¹⁹^ORCID,Jaudzems Kristaps¹⁰^ORCID,Laurents Douglas V.²²^ORCID,Orts Julien²⁴,Pierattelli Roberta¹³¹⁴,Spyroulias Georgios A.¹⁶,Duchardt‐Ferner Elke²³,Ferner Jan¹²^ORCID,Fürtig Boris¹²,Hengesbach Martin¹^ORCID,Löhr Frank²³^ORCID,Qureshi Nusrat¹²^ORCID,Richter Christian¹²^ORCID,Saxena Krishna¹²,Schlundt Andreas²³^ORCID,Sreeramulu Sridhar¹²,Wacker Anna¹²,Weigand Julia E.²⁵^ORCID,Wirmer‐Bartoschek Julia¹²^ORCID,Wöhnert Jens²³,Schwalbe Harald¹²^ORCID

Affiliation:

1. Institute for Organic Chemistry and Chemical Biology Goethe University Frankfurt 60438 Frankfurt am Main Germany

2. Center of Biomolecular Magnetic Resonance (BMRZ) Goethe University Frankfurt, Frankfurt am Main (Germany) Max-von-LaueStrasse 7+9 60438 Frankfurt am Main Germany

3. Institute for Molecular Biosciences Goethe University Frankfurt Max-von-Laue Strasse 7+9 60438 Frankfurt am Main Germany

4. Saverna Therapeutics Pumpmattenweg 3 4105 Biel-Benken Switzerland

5. Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP) Screening Port Schnackenburgallee 114 22525 Hamburg Germany

6. Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD) Theodor-Stern-Kai 7 60596 Frankfurt am Main Germany

7. Institute of Medical Biochemistry Federal University of Rio de Janeiro 21941-902 Rio de Janeiro Brazil

8. National Center of Nuclear Magnetic Resonance (CNRMN), CENABIO Federal University of Rio de Janeiro 21941-902 Rio de Janeiro Brazil

9. Department of Biochemistry Institute of Chemistry Federal University of Rio de Janeiro 21941-902 Rio de Janeiro Brazil

10. Latvian Institute of Organic Synthesis Aizkraukles 21 LV-1006 Riga Latvia

11. ETH Swiss Federal Institute of Technology Laboratory of Physical Chemistry, HCI F217 Vladimir-Prelog-Weg 2 8093 Zürich Switzerland

12. Multiuser Center for Biomolecular Innovation (CMIB) Department of Physics São Paulo State University (UNESP) 01049-010 São José do Rio Preto Brazil

13. Magnetic Resonance Center (CERM) University of Florence Via Luigi Sacconi 6, Sesto Fiorentino 50019 Florence Italy

14. Department of Chemistry “Ugo Schiff” University of Florence Via della Lastruccia 3-13, Sesto Fiorentino 50019 Florence Italy

15. Multidisciplinary Center for Research in Biology (NUMPEX) Campus Duque de Caxias Federal University of Rio de Janeiro 25.250-470 Duque de Caxias Brazil

16. Department of Pharmacy University of Patras 26504 Patras Greece

17. Department of Chemistry University of Torino IT−10126 Torino Italy

18. Laboratory of Toxinology Oswaldo Cruz Foundation (FIOCRUZ) 21040-900 Rio de Janeiro Brazil

19. Department of Molecular Biology and Biophysics UConn Health 263 Farmington Ave. Farmington CT 06030-3305 USA

20. Department of Biochemistry University of Wisconsin-Madison Madison WI 53706 USA

21. Molecular Microbiology and Structural Biochemistry UMR5086 CNRS/Université Lyon 1 7, passage du Vercors 69367 Lyon France

22. “Rocasolano” Institute for Physical Chemistry CSIC 28006 Madrid Spain

23. Laboratory of Chemical Physics National Institute of Diabetes and Digestive and Kidney 20892-0520 Bethesda USA

24. University of Vienna Department of Pharmaceutical Sciences Josef-Holaubek-Platz 2 A-1090 Vienna Austria

25. Department of Biology Technical University of Darmstadt 64289 Darmstadt Germany

Funder

Hessisches Ministerium für Wissenschaft und Kunst

Deutsche Forschungsgemeinschaft

H2020 Research Infrastructures

H2020 Future and Emerging Technologies

FP7 Research Potential of Convergence Regions

Key Laboratory of Dynamic Cognitive System of Electromagnetic Spectrum Space

Fondazione Cassa di Risparmio di Firenze

Agence Nationale de la Recherche

National Institutes of Health

National Science Foundation

Latvijas Zinātnes Padome

Krebsliga Schweiz

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202205858

Reference98 articles.

1. The pandemic’s true death toll: millions more than official counts

2. The need for a multi-level drug targeting strategy to curb the COVID-19 pandemic

3. Drug Discovery Strategies for SARS-CoV-2

4. Evolution of the COVID-19 vaccine development landscape

5. Current Strategies of Antiviral Drug Discovery for COVID-19

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Fragment-to-Lead Medicinal Chemistry Publications in 2022;Journal of Medicinal Chemistry;2024-01-30

2. Targeting the Main Protease (M^pro, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies;ACS Chemical Biology;2024-01-17

3. NMR ¹H,¹⁹F-based screening of the four stem-looped structure 5_SL1–SL4 located in the 5′-untranslated region of SARS-CoV 2 RNA;RSC Medicinal Chemistry;2024

4. Back in Person: Frontiers in Medicinal Chemistry 2023;ChemMedChem;2023-07-24

5. The COVID19‐NMR Consortium: A Public Report on the Impact of this New Global Collaboration;Angewandte Chemie International Edition;2023-02-07