NMR <sup>1</sup>H,<sup>19</sup>F-based screening of the four stem-looped structure 5_SL1–SL4 located in the 5′-untranslated region of SARS-CoV 2 RNA-Reference-Cited by-同舟云学术

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NMR ¹H,¹⁹F-based screening of the four stem-looped structure 5_SL1–SL4 located in the 5′-untranslated region of SARS-CoV 2 RNA

Published:2024 Issue:1 Volume:15 Page:165-177
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Hymon Daniel¹,Martins Jason¹,Richter Christian¹,Sreeramulu Sridhar¹,Wacker Anna¹,Ferner Jan¹,Patwardhan Neeraj N.²,Hargrove Amanda E.²^ORCID,Schwalbe Harald¹^ORCID

Affiliation:

1. Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt/Main, Germany

2. Department of Chemistry, Duke University, Durham, North Carolina 27708, USA

Abstract

Exploring the benefits and limits of ligand based combined 1H and 19F NMR readout for interaction studies of viral RNAs with small compounds.

Funder

Directorate-General XII, Science, Research, and Development

Deutsche Forschungsgemeinschaft

Hessisches Ministerium für Wissenschaft und Kunst

NIH Clinical Center

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00322A

Reference49 articles.

1. The way of SARS-CoV-2 vaccine development: success and challenges

2. Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

3. Merck’s COVID pill loses its lustre: what that means for the pandemic

4. Efficacy and safety of Paxlovid in severe adult patients with SARS-Cov-2 infection: a multicenter randomized controlled study

5. Why scientists are racing to develop more COVID antivirals

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