Targeting the Main Protease (Mpro, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies

Author:

Altincekic Nadide12,Jores Nathalie12,Löhr Frank23ORCID,Richter Christian12,Ehrhardt Claus4,Blommers Marcel J. J.5,Berg Hannes12,Öztürk Sare1,Gande Santosh L.12,Linhard Verena12,Orts Julien6ORCID,Abi Saad Marie Jose6,Bütikofer Matthias7,Kaderli Janina7ORCID,Karlsson B. Göran89,Brath Ulrika8,Hedenström Mattias10,Gröbner Gerhard10,Sauer Uwe H.11,Perrakis Anastassis12ORCID,Langer Julian13ORCID,Banci Lucia1415ORCID,Cantini Francesca1415,Fragai Marco1415ORCID,Grifagni Deborah14,Barthel Tatjana16ORCID,Wollenhaupt Jan16,Weiss Manfred S.16ORCID,Robertson Angus17,Bax Adriaan17ORCID,Sreeramulu Sridhar12,Schwalbe Harald12ORCID

Affiliation:

1. Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany

2. Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany

3. Institute of Biophysical Chemistry, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany

4. Department of Biochemistry, University of Zurich, 8093 Zurich, Switzerland

5. SavernaTherapeutics, 4105 Biel-Benken, Switzerland

6. Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria

7. Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, ETH Zurich, 8093 Zürich, Switzerland

8. Swedish NMR Centre, Department of Chemistry and Molecular Biology, University of Gothenburg, SE40530 Göteborg, Sweden

9. SciLifeLab, University of Gothenburg, SE40530 Göteborg, Sweden

10. Swedish NMR Centre, Department of Chemistry, University of Umeå, SE-90187 Umeå, Sweden

11. Protein Production Sweden, Department of Chemistry, University of Umeå, SE-90187 Umeå, Sweden

12. Oncode Institute and Division of Biochemistry, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands

13. Max Planck Institute of Biophysics, D-60438 Frankfurt am Main, Germany

14. Magnetic Resonance Center and Department of Chemistry, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy

15. Consorzio Interuniversitario Risonanze Magnetiche Metalloproteine, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy

16. Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, D-12489 Berlin, Germany

17. NIH, LCP NIDDK, Bethesda, Maryland 20892, United States

Funder

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Agenzia Nazionale di Valutazione del Sistema Universitario e della Ricerca

National Institute of Diabetes and Digestive and Kidney Diseases

Deutsche Forschungsgemeinschaft

Krebsliga Schweiz

Knut och Alice Wallenbergs Stiftelse

H2020 Research Infrastructures

Hessisches Ministerium f?r Wissenschaft und Kunst

Goethe-Universit?t Frankfurt am Main

Publisher

American Chemical Society (ACS)

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