Simultaneous determination of notoginsenoside R1 and ginsenoside Re in rat plasma by ultra high performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study

Author:

Dai Guoliang1,Jiang Zhitao2,Zhu Lijing1,Zhang Qian1,Zong Yang1,Liu Shijia1,Li Changyin1,Ju Wenzheng1

Affiliation:

1. Department of Clinical Pharmacology; Affiliated Hospital of Nanjing University of Traditional Chinese Medicine; Nanjing China

2. Department of Pharmacy Office; Zhangjiagang Hospital of Traditional Chinese Medicine; Zhangjiagang China

Funder

National Natural Science Foundation of China

Administration of Traditional Chinese Medicine of Jiangsu Province

National Science and Technology Major Project Creation of Major New Drugs from China

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

Reference20 articles.

1. Saponins of panax notoginseng: chemistry, cellular targets and therapeutic opportunities in cardiovascular diseases;Liu;Expert Opin. Investig. Drugs,2014

2. Synergistic protective effects of salvianolic acids and panax notoginseng saponins on cardiomyocytes with hypoxia-reoxygenation injury;Gong;China J. Chin. Mater. Med.,2013

3. Protective effects of panax notoginseng saponins on cardiovascular diseases: a comprehensive overview of experimental studies;Yang;Evid. Based Complement. Alternat. Med.,2014

4. Oral panax notoginseng preparation for coronary heart disease: a systematic review of randomized controlled trials;Shang;Evid. Based Complement. Alternat. Med.,2013

5. Panax notoginseng saponins promotes stroke recovery by influencing expression of Nogo-A, NgR and p75NGF, in vitro and in vivo;Liu;Biol. Pharm. Bull.,2014

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