Amyloid‐Related Imaging Abnormalities in the DIAN‐TU ‐001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease

Author:

Joseph‐Mathurin Nelly1ORCID,Llibre‐Guerra Jorge J.2,Li Yan2,McCullough Austin A.1,Hofmann Carsten3,Wojtowicz Jakub4,Park Ethan5,Wang Guoqiao5,Preboske Gregory M.6,Wang Qing1,Gordon Brian A.1ORCID,Chen Charles D.1ORCID,Flores Shaney1,Aggarwal Neelum T.7,Berman Sarah B.8,Bird Thomas D.9,Black Sandra E.10,Borowski Bret6,Brooks William S.11,Chhatwal Jasmeer P.12,Clarnette Roger13,Cruchaga Carlos14,Fagan Anne M.2,Farlow Martin15,Fox Nick C.16,Gauthier Serge17,Hassenstab Jason118,Hobbs Diana A.1,Holdridge Karen C.19,Honig Lawrence S.20,Hornbeck Russ C.1,Hsiung Ging‐Yuek R.21,Jack Clifford R.6,Jimenez‐Velazquez Ivonne Z.22,Jucker Mathias23ORCID,Klein Gregory24,Levin Johannes25,Mancini Michele19,Masellis Mario10,McKay Nicole S.1,Mummery Catherine J.16,Ringman John M.26ORCID,Shimada Hiroyuki27,Snider B. Joy2,Suzuki Kazushi28,Wallon David29,Xiong Chengjie5,Yaari Roy19,McDade Eric2,Perrin Richard J.230,Bateman Randall J.2,Salloway Stephen P.31ORCID,Benzinger Tammie L.S.1ORCID,Clifford David B.2,

Affiliation:

1. Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis MO

2. Department of Neurology Washington University School of Medicine St. Louis MO

3. Pharmaceutical Sciences, Roche Innovation Center Basel F. Hoffmann‐La Roche Ltd. Basel Switzerland

4. Product Development, Clinical Safety F. Hoffmann‐La Roche Ltd. Basel Switzerland

5. Division of Biostatistics Washington University School of Medicine St. Louis MO

6. Department of Radiology Mayo Clinic Rochester MN

7. Department of Neurological Sciences Rush University Medical Center Chicago IL

8. Departments of Neurology and Clinical and Translational Science University of Pittsburgh Pittsburgh PA

9. Department of Neurology University of Washington Seattle WA

10. Department of Medicine (Neurology), Sunnybrook Health Sciences Centre Sunnybrook Research Institute, University of Toronto Toronto Ontario Canada

11. Neuroscience Research Australia University of New South Wales New South Wales Australia

12. Department of Neurology Brigham and Women's Hospital, Massachusetts General Hospital Boston MA

13. Department of Internal Medicine, Medical School University of Western Australia Crawley Australia

14. Department of Psychiatry Washington University School of Medicine St. Louis MO

15. Department of Neurology Indiana University School of Medicine Indianapolis IN

16. UCL Queen Square Institute of Neurology University College London London UK

17. McGill Center for Studies in Aging McGill University Montreal Quebec Canada

18. Psychological and Brain Sciences Washington University School of Medicine St. Louis MO

19. Eli Lilly and Company Indianapolis IN

20. Taub Institute Columbia University Irving Medical Center New York NY

21. Department of Medicine University of British Columbia Vancouver British Columbia Canada

22. Department of Medicine University of Puerto Rico School of Medicine San Juan PR

23. German Center for Neurodegenerative Diseases (DZNE) Hertie Institute for Clinical Brain Research, University of Tübingen Tübingen Germany

24. Clinical Imaging, Biomarkers & Translational Technologies F. Hoffmann‐La Roche Ltd. Basel Switzerland

25. German Center for Neurodegenerative Diseases (DZNE), Department of Neurology, Ludwig‐Maximilians‐Universität München Munich Cluster for Systems Neurology (SyNergy) Munich Germany

26. Department of Neurology, Keck School of Medicine University of Southern California Los Angeles CA

27. Diagnostic and Interventional Radiology, Graduate School of Medicine Osaka City University Osaka Japan

28. Department of Internal Medicine National Defense Medical College Saitama Japan

29. INSERM U1245 Normandie University Rouen France

30. Department of Pathology & Immunology Washington University School of Medicine St. Louis MO

31. Department of Neurology Alpert Medical School of Brown University, Butler Hospital Providence RI

Funder

Alzheimer's Association

National Institute on Aging

National Institutes of Health

Eli Lilly and Company

Roche

Avid Radiopharmaceuticals

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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