Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains

Author:

Johannesson Malin,Söderberg Linda,Zachrisson Olof,Fritz Nicolas,Kylefjord Helen,Gkanatsiou Eleni,Button Emily,Svensson Anne-Sophie,Rachalski Adeline,Nygren Patrik,Osswald Gunilla,Lannfelt Lars,Möller Christer

Publisher

Elsevier BV

Reference35 articles.

1. Two randomized phase 3 studies of aducanumab in early Alzheimer’s disease;Budd Haeberlein;J. Prev Alzheimers Dis.,2022

2. ABBY: a phase 2 randomized trial of crenezumab in mild to moderate Alzheimer disease;Cummings;Neurology,2018

3. Sensitive ELISA detection of amyloid-beta protofibrils in biological samples;Englund;J. Neurochem.,2007

4. A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer’s disease;Gkanatsiou;Neurosci. Lett.,2019

5. Amyloid pathology and synaptic loss in pathological aging;Gkanatsiou;J. Neurochem.,2021

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