Author:
Liu Shu,Li Ang,Liu Yong,Yan Hao,Wang Meng,Sun Yuqing,Fan Lingzhong,Song Ming,Xu Kaibin,Chen Jun,Chen Yunchun,Wang Huaning,Guo Hua,Wan Ping,Lv Luxian,Yang Yongfeng,Li Peng,Lu Lin,Yan Jun,Wang Huiling,Zhang Hongxing,Wu Huawang,Ning Yuping,Zhang Dai,Jiang Tianzi,Liu Bing
Abstract
BackgroundSchizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure and function are a plausible neurobiological characterisation of schizophrenia. However, the polygenic effects of schizophrenia on these imaging endophenotypes have not yet been fully elucidated.AimsTo investigate the effects of polygenic risk for schizophrenia on the brain grey matter volume and functional connectivity, which are disrupted in schizophrenia.MethodGenomic and neuroimaging data from a large sample of Han Chinese patients with schizophrenia (N = 509) and healthy controls (N = 502) were included in this study. We examined grey matter volume and functional connectivity via structural and functional magnetic resonance imaging, respectively. Using the data from a recent meta-analysis of a genome-wide association study that comprised a large number of Chinese people, we calculated a polygenic risk score (PGRS) for each participant.ResultsThe imaging genetic analysis revealed that the individual PGRS showed a significantly negative correlation with the hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity, both of which were lower in the people with schizophrenia than in the controls. We also found that the observed neuroimaging measures showed weak but similar changes in unaffected first-degree relatives of patients with schizophrenia.ConclusionsThese findings suggested that genetically influenced brain grey matter volume and functional connectivity may provide important clues for understanding the pathological mechanisms of schizophrenia and for the early diagnosis of schizophrenia.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
34 articles.
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