Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Author:

Franke Barbara, ,Stein Jason L,Ripke Stephan,Anttila Verneri,Hibar Derrek P,van Hulzen Kimm J E,Arias-Vasquez Alejandro,Smoller Jordan W,Nichols Thomas E,Neale Michael C,McIntosh Andrew M,Lee Phil,McMahon Francis J,Meyer-Lindenberg Andreas,Mattheisen Manuel,Andreassen Ole A,Gruber Oliver,Sachdev Perminder S,Roiz-Santiañez Roberto,Saykin Andrew J,Ehrlich Stefan,Mather Karen A,Turner Jessica A,Schwarz Emanuel,Thalamuthu Anbupalam,Yao Yin,Ho Yvonne Y W,Martin Nicholas G,Wright Margaret J,O'Donovan Michael C,Thompson Paul M,Neale Benjamin M,Medland Sarah E,Sullivan Patrick FORCID,

Publisher

Springer Science and Business Media LLC

Subject

General Neuroscience

Reference38 articles.

1. Sullivan, P.F., Daly, M.J. & O'Donovan, M. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat. Rev. Genet. 13, 537–551 (2012).

2. Purcell, S.M. et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature 506, 185–190 (2014).

3. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014).

4. Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat. Neurosci. 18, 199–209 (2015).

5. van Erp, T.G. et al. Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol. Psychiatry 10.1038/mp.2015.63 (2 June 2015).

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