ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells

Author:

Kai FuiBoon1,Ou Guanqing1,Tourdot Richard W23,Stashko Connor1,Gaietta Guido4,Swift Mark F4ORCID,Volkmann Niels45ORCID,Long Alexandra F67,Han Yulong8,Huang Hector H9ORCID,Northey Jason J1,Leidal Andrew M10ORCID,Viasnoff Virgile11,Bryant David M12ORCID,Guo Wei13,Wiita Arun P9,Guo Ming8,Dumont Sophie714ORCID,Hanein Dorit415ORCID,Radhakrishnan Ravi23ORCID,Weaver Valerie M11617ORCID

Affiliation:

1. Department of Surgery, Center for Bioengineering and Tissue Regeneration University of California San Francisco San Francisco CA USA

2. Department of Bioengineering University of Pennsylvania Philadelphia PA USA

3. Department of Chemical and Biomolecular Engineering University of Pennsylvania Philadelphia PA USA

4. Scintillon Institute San Diego CA USA

5. Structural Image Analysis Unit, Department of Structural Biology and Chemistry, Institut Pasteur Université Paris Cité, CNRS UMR3528 Paris France

6. Tetrad Graduate Program University of California San Francisco San Francisco CA USA

7. Department of Bioengineering and Therapeutic Sciences Department of Cell & Tissue Biology, University of California San Francisco San Francisco CA USA

8. Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA USA

9. Department of Laboratory Medicine University of California San Francisco San Francisco CA USA

10. Department of Pathology University of California San Francisco San Francisco CA USA

11. Mechanobiology Institute National University of Singapore Singapore City Singapore

12. Cancer Research UK Beatson Institute Glasgow UK

13. Department of Biology University of Pennsylvania Philadelphia PA USA

14. Chan Zuckerberg Biohub San Francisco CA USA

15. Structural Studies of Macromolecular Machines in Cellulo Unit, Department of Structural Biology and Chemistry, Institut Pasteur Université Paris Cité, CNRS UMR3528 Paris France

16. Departments of Radiation Oncology and Bioengineering and Therapeutic Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research University of California San Francisco San Francisco CA USA

17. UCSF Helen Diller Family Comprehensive Cancer Center University of California San Francisco San Francisco CA USA

Funder

American Association for Cancer Research

Banting Research Foundation

Breast Cancer Research Foundation

Canadian Institutes of Health Research

National Institutes of Health

National Institute of General Medical Sciences

National Science Foundation

Pew Charitable Trusts

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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