Abstract
AbstractYAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.
Funder
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
AHA postdoctoral fellowship
Fonds Wetenschappelijk Onderzoek
American Cancer Society
U.S. Department of Health & Human Services | NIH | National Cancer Institute
Wu Tsai Human Performance Alliance at UCSD
Publisher
Springer Science and Business Media LLC