A Combined Synthetic and DFT Study on the Catalyst-Free and Solvent-Assisted Synthesis of 1,3,4-Oxadiazole-2-thiol Derivatives-Reference-Cited by-同舟云学术

A Combined Synthetic and DFT Study on the Catalyst-Free and Solvent-Assisted Synthesis of 1,3,4-Oxadiazole-2-thiol Derivatives

Published:2013 Issue: Volume:2013 Page:1-6
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Soleiman-Beigi Mohammad¹,Aryan Reza²,Yousofizadeh Maryam¹,Khosravi Shima¹

Affiliation:

1. Department of Chemistry, Ilam University, P.O. Box 69315-516, Ilam, Iran

2. Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran

Abstract

A novel practical and efficient catalyst-free method for the synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols has been developed, which is assisted by reaction solvent (DMF). The solvent effects on product selectivity were studied based on Onsager’s reaction field theory of electrostatic solvation. The ab initio theoretical studies on the effect of solvents on the process also supported the suitability of DMF as the reaction medium for the preparation of 1,3,4-oxadiazole-2-thiol derivatives.

Funder

Ilam University Research Council

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2013/476358.pdf

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