Long Noncoding RNAs-Related Diseases, Cancers, and Drugs

Author:

Tang Jen-Yang123ORCID,Lee Jin-Ching4,Chang Yung-Ting5,Hou Ming-Feng367,Huang Hurng-Wern8,Liaw Chih-Chuang59ORCID,Chang Hsueh-Wei31011

Affiliation:

1. Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

2. Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

3. Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

4. Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan

5. Doctor Degree Program in Marine Biotechnology, National Sun Yat-sen University/Academia Sinica, Kaohsiung, Taiwan

6. Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

7. Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan

8. Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan

9. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan

10. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan

11. Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

Abstract

Long noncoding RNA (lncRNA) function is described in terms of related gene expressions, diseases, and cancers as well as their polymorphisms. Potential modulators of lncRNA function, including clinical drugs, natural products, and derivatives, are discussed, and bioinformatic resources are summarized. The improving knowledge of the lncRNA regulatory network has implications not only in gene expression, diseases, and cancers, but also in the development of lncRNA-based pharmacology.

Funder

National Science Council

Publisher

Hindawi Limited

Subject

General Environmental Science,General Biochemistry, Genetics and Molecular Biology,General Medicine

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