The Transcriptional Landscape of the Mammalian Genome-Reference-Cited by-同舟云学术

The Transcriptional Landscape of the Mammalian Genome

Published:2005-09-02 Issue:5740 Volume:309 Page:1559-1563
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Carninci P.¹,Kasukawa T.¹,Katayama S.¹,Gough J.¹,Frith M. C.¹,Maeda N.¹,Oyama R.¹,Ravasi T.¹,Lenhard B.¹,Wells C.¹,Kodzius R.¹,Shimokawa K.¹,Bajic V. B.¹,Brenner S. E.¹,Batalov S.¹,Forrest A. R. R.¹,Zavolan M.¹,Davis M. J.¹,Wilming L. G.¹,Aidinis V.¹,Allen J. E.¹,Ambesi-Impiombato A.¹,Apweiler R.¹,Aturaliya R. N.¹,Bailey T. L.¹,Bansal M.¹,Baxter L.¹,Beisel K. W.¹,Bersano T.¹,Bono H.¹,Chalk A. M.¹,Chiu K. P.¹,Choudhary V.¹,Christoffels A.¹,Clutterbuck D. R.¹,Crowe M. L.¹,Dalla E.¹,Dalrymple B. P.¹,de Bono B.¹,Gatta G. Della¹,di Bernardo D.¹,Down T.¹,Engstrom P.¹,Fagiolini M.¹,Faulkner G.¹,Fletcher C. F.¹,Fukushima T.¹,Furuno M.¹,Futaki S.¹,Gariboldi M.¹,Georgii-Hemming P.¹,Gingeras T. R.¹,Gojobori T.¹,Green R. E.¹,Gustincich S.¹,Harbers M.¹,Hayashi Y.¹,Hensch T. K.¹,Hirokawa N.¹,Hill D.¹,Huminiecki L.¹,Iacono M.¹,Ikeo K.¹,Iwama A.¹,Ishikawa T.¹,Jakt M.¹,Kanapin A.¹,Katoh M.¹,Kawasawa Y.¹,Kelso J.¹,Kitamura H.¹,Kitano H.¹,Kollias G.¹,Krishnan S. P. T.¹,Kruger A.¹,Kummerfeld S. K.¹,Kurochkin I. V.¹,Lareau L. F.¹,Lazarevic D.¹,Lipovich L.¹,Liu J.¹,Liuni S.¹,McWilliam S.¹,Babu M. Madan¹,Madera M.¹,Marchionni L.¹,Matsuda H.¹,Matsuzawa S.¹,Miki H.¹,Mignone F.¹,Miyake S.¹,Morris K.¹,Mottagui-Tabar S.¹,Mulder N.¹,Nakano N.¹,Nakauchi H.¹,Ng P.¹,Nilsson R.¹,Nishiguchi S.¹,Nishikawa S.¹,Nori F.¹,Ohara O.¹,Okazaki Y.¹,Orlando V.¹,Pang K. C.¹,Pavan W. J.¹,Pavesi G.¹,Pesole G.¹,Petrovsky N.¹,Piazza S.¹,Reed J.¹,Reid J. F.¹,Ring B. Z.¹,Ringwald M.¹,Rost B.¹,Ruan Y.¹,Salzberg S. L.¹,Sandelin A.¹,Schneider C.¹,Schönbach C.¹,Sekiguchi K.¹,Semple C. A. M.¹,Seno S.¹,Sessa L.¹,Sheng Y.¹,Shibata Y.¹,Shimada H.¹,Shimada K.¹,Silva D.¹,Sinclair B.¹,Sperling S.¹,Stupka E.¹,Sugiura K.¹,Sultana R.¹,Takenaka Y.¹,Taki K.¹,Tammoja K.¹,Tan S. L.¹,Tang S.¹,Taylor M. S.¹,Tegner J.¹,Teichmann S. A.¹,Ueda H. R.¹,van Nimwegen E.¹,Verardo R.¹,Wei C. L.¹,Yagi K.¹,Yamanishi H.¹,Zabarovsky E.¹,Zhu S.¹,Zimmer A.¹,Hide W.¹,Bult C.¹,Grimmond S. M.¹,Teasdale R. D.¹,Liu E. T.¹,Brusic V.¹,Quackenbush J.¹,Wahlestedt C.¹,Mattick J. S.¹,Hume D. A.¹,Kai C.¹,Sasaki D.¹,Tomaru Y.¹,Fukuda S.¹,Kanamori-Katayama M.¹,Suzuki M.¹,Aoki J.¹,Arakawa T.¹,Iida J.¹,Imamura K.¹,Itoh M.¹,Kato T.¹,Kawaji H.¹,Kawagashira N.¹,Kawashima T.¹,Kojima M.¹,Kondo S.¹,Konno H.¹,Nakano K.¹,Ninomiya N.¹,Nishio T.¹,Okada M.¹,Plessy C.¹,Shibata K.¹,Shiraki T.¹,Suzuki S.¹,Tagami M.¹,Waki K.¹,Watahiki A.¹,Okamura-Oho Y.¹,Suzuki H.¹,Kawai J.¹,Hayashizaki Y.¹

Affiliation:

1. Affiliations can be found on Science Online (available at ).

Abstract

This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5′ and 3′ boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference27 articles.

1. Targeting a Complex Transcriptome: The Construction of the Mouse Full-Length cDNA Encyclopedia

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