Effect of Endomorphins on HUVECs Treated by ox-LDL and Its Related Mechanisms-Reference-Cited by-同舟云学术

Effect of Endomorphins on HUVECs Treated by ox-LDL and Its Related Mechanisms

Published:2016 Issue: Volume:2016 Page:1-8
ISSN:2314-6745
Container-title:Journal of Diabetes Research
language:en
Short-container-title:Journal of Diabetes Research

Author:

Zhao Juan¹,Zhang Qi²,Liu Jing²^ORCID,Tian Liming²,Huang Wenhui¹,Quan Jinxing²,Wang Jinyang²,Xu Yanjia²,Wang Yunfang²,Niu Ruilan²

Affiliation:

1. Department of Endocrinology, Gansu Provincial Hospital, 204 West Donggang Road, Lanzhou, Gansu 730000, China

2. Department of Nephrology, Gansu Provincial Hospital, 204 West Donggang Road, Lanzhou, Gansu 730000, China

Abstract

We found in the present study that treatment with ox-LDL decreased the cell viability and the content of nitric oxide (NO) and the activity of nitric oxide synthase (NOS) as well as eNOS mRNA expression, while increasing the mRNA expression and content of endothelin-1 (ET-1) in human umbilical vein endothelial cells (HUVECs). However, endomorphins EM1/EM2 increased the cell viability and the content of NO and the activity of NOS as well as eNOS mRNA expression, while decreasing the mRNA expression and content of ET-1 compared with ox-LDL alone. Meanwhile, the expressions of JNK and p-JNK were enhanced by ox-LDL while being suppressed by EM1/EM2. The results suggested that EM1 and EM2 can correct the endothelial cell dysfunction induced by ox-LDL and the protective effect may be achieved by affecting the JNK pathway.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Link

http://downloads.hindawi.com/journals/jdr/2016/9741483.pdf

Reference27 articles.

1. In Type 2 Diabetes, Rosiglitazone Therapy for Insulin Resistance Ameliorates Endothelial Dysfunction Independent of Glucose Control

2. Endothelial Function

3. High-Glucose–Triggered Apoptosis in Cultured Endothelial Cells

4. Hypertension, the endothelial cell, and the vascular complications of diabetes mellitus.

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