Plasma S-Adenosylmethionine Is Associated with Lung Injury in COVID-19

Author:

Kryukov Evgeny Vladimirovich1ORCID,Ivanov Alexander Vladimirovich2ORCID,Karpov Vladimir Olegovich1,Vasil’evich Aleksandrin Valery2,Dygai Alexander Mikhaylovich2ORCID,Kruglova Maria Petrovna3ORCID,Kostiuchenko Gennady Ivanovich4,Kazakov Sergei Petrovich1,Kubatiev Aslan Amirkhanovich2ORCID

Affiliation:

1. Burdenko Main Military Clinical Hospital, Ministry of Defense, Gospitalnaya Sq., 3, Moscow, 105229, Russia

2. Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, Moscow, 125315, Russia

3. Sechenov First Moscow State Medical University, Trubetskaya St., 8-2, Moscow, 119991, Russia

4. Regional Clinical Hospital, Lyapidevsky St., 1, Barnaul, 656024, Russia

Abstract

Objective. S-Adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are indicators of global transmethylation and may play an important role as markers of severity of COVID-19. Methods. The levels of plasma SAM and SAH were determined in patients admitted with COVID-19 ( n = 56 , mean age = 61 ). Lung injury was identified by computed tomography (CT) in accordance with the CT0-4 classification. Results. SAM was found to be a potential marker of lung damage risk in COVID-19 patients ( SAM > 80 nM ; CT3,4 vs. CT 0-2: relative ratio (RR) was 3.0; p = 0.0029 ). SAM / SAH > 6.0 was also found to be a marker of lung injury (CT2-4 vs. CT0,1: RR = 3.47 , p = 0.0004 ). There was a negative association between SAM and glutathione level ( ρ = 0.343 , p = 0.011 ). Interleukin-6 (IL-6) levels were associated with SAM ( ρ = 0.44 , p = 0.01 ) and SAH ( ρ = 0.534 , p = 0.001 ) levels. Conclusions. A high SAM level and high methylation index are associated with the risk of lung injury in patients with COVID-19. The association of SAM with IL-6 and glutathione indicates an important role of transmethylation in the development of cytokine imbalance and oxidative stress in patients with COVID-19.

Funder

Russian Foundation for Basic Research

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

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