Author:
Bellan Mattia,Patti Giuseppe,Hayden Eyal,Azzolina Danila,Pirisi Mario,Acquaviva Antonio,Aimaretti Gianluca,Aluffi Valletti Paolo,Angilletta Roberto,Arioli Roberto,Avanzi Gian Carlo,Avino Gianluca,Balbo Piero Emilio,Baldon Giulia,Baorda Francesca,Barbero Emanuela,Baricich Alessio,Barini Michela,Barone-Adesi Francesco,Battistini Sofia,Beltrame Michela,Bertoli Matteo,Bertolin Stephanie,Bertolotti Marinella,Betti Marta,Bobbio Flavio,Boffano Paolo,Boglione Lucio,Borrè Silvio,Brucoli Matteo,Calzaducca Elisa,Cammarata Edoardo,Cantaluppi Vincenzo,Cantello Roberto,Capponi Andrea,Carriero Alessandro,Casciaro Francesco Giuseppe,Castello Luigi Mario,Ceruti Federico,Chichino Guido,Chirico Emilio,Cisari Carlo,Cittone Micol Giulia,Colombo Crizia,Comi Cristoforo,Croce Eleonora,Daffara Tommaso,Danna Pietro,Della Corte Francesco,De Vecchi Simona,Dianzani Umberto,Di Benedetto Davide,Esposto Elia,Faggiano Fabrizio,Falaschi Zeno,Ferrante Daniela,Ferrero Alice,Gagliardi Ileana,Gaidano Gianluca,Galbiati Alessandra,Gallo Silvia,Garavelli Pietro Luigi,Gardino Clara Ada,Garzaro Massimiliano,Gastaldello Maria Luisa,Gavelli Francesco,Gennari Alessandra,Giacomini Greta Maria,Giacone Irene,Giai Via Valentina,Giolitti Francesca,Gironi Laura Cristina,Gramaglia Carla,Grisafi Leonardo,Inserra Ilaria,Invernizzi Marco,Krengli Marco,Labella Emanuela,Landi Irene Cecilia,Landi Raffaella,Leone Ilaria,Lio Veronica,Lorenzini Luca,Maconi Antonio,Malerba Mario,Manfredi Giulia Francesca,Martelli Maria,Marzari Letizia,Marzullo Paolo,Mennuni Marco,Montabone Claudia,Morosini Umberto,Mussa Marco,Nerici Ilaria,Nuzzo Alessandro,Olivieri Carlo,Padelli Samuel Alberto,Panella Massimiliano,Parisini Andrea,Paschè Alessio,Pau Alberto,Pedrinelli Anita Rebecca,Percivale Ilaria,Re Roberta,Rigamonti Cristina,Rizzi Eleonora,Rognoni Andrea,Roveta Annalisa,Salamina Luigia,Santagostino Matteo,Saraceno Massimo,Savoia Paola,Sciarra Marco,Schimmenti Andrea,Scotti Lorenza,Spinoni Enrico,Smirne Carlo,Tarantino Vanessa,Tillio Paolo Amedeo,Vaschetto Rosanna,Vassia Veronica,Zagaria Domenico,Zavattaro Elisa,Zeppegno Patrizia,Zottarelli Francesca,Sainaghi Pier Paolo
Abstract
AbstractClinical features and natural history of coronavirus disease 2019 (COVID-19) differ widely among different countries and during different phases of the pandemia. Here, we aimed to evaluate the case fatality rate (CFR) and to identify predictors of mortality in a cohort of COVID-19 patients admitted to three hospitals of Northern Italy between March 1 and April 28, 2020. All these patients had a confirmed diagnosis of SARS-CoV-2 infection by molecular methods. During the study period 504/1697 patients died; thus, overall CFR was 29.7%. We looked for predictors of mortality in a subgroup of 486 patients (239 males, 59%; median age 71 years) for whom sufficient clinical data were available at data cut-off. Among the demographic and clinical variables considered, age, a diagnosis of cancer, obesity and current smoking independently predicted mortality. When laboratory data were added to the model in a further subgroup of patients, age, the diagnosis of cancer, and the baseline PaO2/FiO2 ratio were identified as independent predictors of mortality. In conclusion, the CFR of hospitalized patients in Northern Italy during the ascending phase of the COVID-19 pandemic approached 30%. The identification of mortality predictors might contribute to better stratification of individual patient risk.
Publisher
Springer Science and Business Media LLC