Cytokines and Chemokines in Irritant Contact Dermatitis

Author:

Lee Haur Yueh1,Stieger Marco1,Yawalkar Nikhil1ORCID,Kakeda Masato12ORCID

Affiliation:

1. Department of Dermatology, Inselspital, University of Bern, 3010 Bern, Switzerland

2. Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan

Abstract

Irritant contact dermatitis is a result of activated innate immune response to various external stimuli and consists of complex interplay which involves skin barrier disruption, cellular changes, and release of proinflammatory mediators. In this review, we will focus on key cytokines and chemokines involved in the pathogenesis of irritant contact dermatitis and also contrast the differences between allergic contact dermatitis and irritant contact dermatitis.

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

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