Human relevance of in vivo and in vitro skin irritation tests for hazard classification of pesticides

Author:

Raabe Hans A.1,Costin Gertrude-Emilia1,Allen David G.2,Lowit Anna3,Corvaro Marco4,O’Dell Lindsay3,Breeden-Alemi Julie3,Page Kathryn5,Perron Monique3,Flint Silva Tara3,Westerink Walter6,Baker Elizabeth7,Sullivan Kristie1

Affiliation:

1. Institute for In Vitro Sciences, Gaithersburg, MD, USA

2. Inotiv, Durham, NC, USA

3. US Environmental Protection Agency, Washington, DC, USA

4. Corteva Agriscience, Rome, Italy

5. The Clorox Company, San Francisco, CA, USA

6. Charles River Laboratories, Den Bosch, The Netherlands

7. Physicians Committee for Responsible Medicine, Washington, DC, USA

Funder

Carroll Petrie Foundation

Publisher

Informa UK Limited

Reference100 articles.

1. Non-animal methods to predict skin sensitization (II): an assessment of defined approaches

2. Improved defined approaches for predicting skin sensitization hazard and potency in humans

3. Guideline OECD. No. 497: Defined Approaches on Skin Sensitisation [Internet]. 2023. Available from: https://www.oecd-ilibrary.org/content/publication/b92879a4-en.

4. EPA. Interim science policy: use of alternative approaches for skin sensitization as a replacement for laboratory animal testing draft for public comment [Internet]. 2018. Available from: https://www.regulations.gov/document/EPA-HQ-OPP-2016-0093-0090.

5. Performance of the GHS Mixtures Equation for Predicting Acute Oral Toxicity

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