Affiliation:
1. Chemistry Department, Faculty of Science, Jazan University, Jazan, 45142, Kingdom of Saudi Arabia
Abstract
Abstract:
In ethanolic piperidine solution, the interaction of 6-bromonaphthalen-2-ol (1) with α-
cyano-p-chlorocinnamonitrile (2a) or ethyl α-cyano-p-chlorocinnamate (2b) yielded 4Hnaphtho[
2,1-b]pyran-3-carbonitrile (3a) and 4H-naphtho[2,1-b]pyran-3-carboxylate (3b). The
naphthopyran derivatives (3a, b) reacted with electrophilic reagents afforded naphthopyranopyrimidines
and naphthopyrano-triazolopyrimidine derivatives. The structures of the newly synthesized
compounds are confirmed through spectral analysis using NMR, IR, and MS spectroscopy.
The anticancer efficacy of all compounds was investigated against three cancer cell lines: MCF-
7, HeLa, and PC-3, along with a molecular docking study.
Funder
Deputyship for Research & Innovation, Ministry of Higher Education in Saudi Arabia
Publisher
Bentham Science Publishers Ltd.