Extensive SAR and Computational Studies of 3-{4-[(Benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) Derivatives-Reference-Cited by-同舟云学术

Extensive SAR and Computational Studies of 3-{4-[(Benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) Derivatives

Published:2007-07-26 Issue:17 Volume:50 Page:4250-4254
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Piazzi Lorna¹,Cavalli Andrea¹,Belluti Federica¹,Bisi Alessandra¹,Gobbi Silvia¹,Rizzo Stefano¹,Bartolini Manuela¹,Andrisano Vincenza¹,Recanatini Maurizio¹,Rampa Angela¹

Affiliation:

1. Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070100g

Reference16 articles.

1. A Century of Alzheimer's Disease

2. The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development

3. A Structural Motif of Acetylcholinesterase That Promotes Amyloid β-Peptide Fibril Formation

4. 3-(4-{[Benzyl(methyl)amino]methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) Inhibits Both Acetylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation: A Dual Function Lead for Alzheimer's Disease Therapy

5. Central Selective Acetylcholinesterase Inhibitor with Neurotrophic Activity Structure-Activity Relationships of TAK-147 and Related Compounds

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