The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer-Reference-Cited by-同舟云学术

The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer

Published:2022-09 Issue:32 Volume:28 Page:2677-2685
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Moradi-Marjaneh Reyhaneh¹,Marjaneh Mahdi Moradi²^ORCID,Asgharzadeh Fereshteh³

Affiliation:

1. Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

2. Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom

3. Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Abstract: The incidence of colorectal cancer (CRC) has significantly increased in recent decades, which has made this disease an important global health issue. Despite many efforts, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (Hsp27) is one of the most studied members of Hsp family. It has attracted particular attention in CRC pathogenesis, since it is involved in fundamental cell functions for cell survival. Evidence show that Hsp27 plays important roles in CRC progression and metastasis. Hsp27 overexpression has been observed in CRC and suggested to be associated with CRC poor prognosis. In the present review, we focus on the current knowledge on the role of Hsp27 in CRC carcinogenesis and the underlying mechanisms. In addition, we discuss the value of targeting Hsp27 in CRC treatment.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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