Author:
Vidyasagar Aparna,Wilson Nancy A,Djamali Arjang
Abstract
Abstract
Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in different disease states playing both protective and counter-protective roles. The current review presents HSP27 in multiple disease contexts: renal injury and fibrosis, cancer, neuro-degenerative and cardiovascular disease, highlighting its role as a potential biomarker and therapeutic target.
Publisher
Springer Science and Business Media LLC
Subject
Gastroenterology,Dermatology,Hepatology,Rheumatology,Medicine (miscellaneous)
Cited by
245 articles.
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