Affiliation:
1. Department of Chemistry, Faculty of Science, King Abdul Aziz University, P.O. Box 42805 Jeddah, 21551, Saudi Arabia
Abstract
In recent years, a very interest in the synthesis of functionalized 3-thioxo-1,2,4-triazin-5-
ones and their derivatives as vital probes has been increased, due to the important, applications of the
medicinal, pharmacological, and biological field as a drug, semi drug, and bioactive systems. The present
work review outlines extensive recent advances literature survey on the synthesis of sulfurbearing
1,2,4-triazin-5-one derivatives has been reconsidered. Also, the behavior of these family towards
electrophilic and nucleophilic reagents in different media and conditions reported. The biological
evaluation of the most synthesized systems included anticancer, anti-HIV, antimicrobial as well as
their enzymatic effects (cellobiase produced by fungi) have been reported. The reactivity of these systems
depends on the polarity of solvent, temperature, molarity as well as a type of tautomeric present.
Publisher
Bentham Science Publishers Ltd.
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