Affiliation:
1. Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
2. Department of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi Arabia
Abstract
3-Amino-1,2,4-triazines are considered versatile compounds for its significance as building
blocks in synthetic and pharmaceutical chemistry. The synthesis, chemical reactivity, and applications
of substituted 1,2,4-triazines bearing an amino group were described in this review. The presence
of the amino group at position 3 exhibited unique reactivities towards carbonitrile, carbonyl and
isothiocyanate reagents. The reactions were divided into several categories, depending on the other
substituents on the 1,2,4-triazine ring. In this review, relevant and appropriate applications of the
synthesized, isolated, and condensed heterocycles derivatives were reported.
Publisher
Bentham Science Publishers Ltd.
Cited by
3 articles.
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