Affiliation:
1. Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
Abstract
:
This review reports various synthetic routes of pyrazolone/ pyrazolinone derivatives via
the addition of cycloaddition, condensation, cyclocondensation, modification, alkylation, as well as
formylation, regioselective, and ring-opening reactions under reflux, microwave irradiation, and/ or
ultrasonication conditions. It also presents critical chemical behaviors towards nucleophilic and electrophilic
reagents. The chemical reactivities of pyrazolone/ pyrazolinone derivatives involve alkylation,
acylation, condensation, catalyzed diazo coupling, oxidation, heteroarylation, phosphorylation,
stereoselective alkenylation, enantioselective alkylation, addition, and complexation reactions. The
review also summarizes the significant biological activity of pyrazolone/ pyrazolinone derivatives as
antibacterial, antifungal, anti-inflammatory, anticancer, antitumor, anthelmintic, analgesic, as well as
antioxidant, anthelmintic, antibiofilm, and anti-HIV. Moreover, some pyrazolone/ pyrazolinone derivatives
used to remove various metal or soft metal ions from the wastewater. Besides, they exhibited
stable complexes with some metals, for example, Ag (I), Cu (I), Cu (II), Hg (II), Pb (II), Sn (II),
and Sb (V) as new materials, catalysis, and precursors for CVD in the microelectronic industry and
as potential antitumoral.
Funder
Sichuan Provincial Department of science and technology support program
Southwest Minzu University
Publisher
Bentham Science Publishers Ltd.