Affiliation:
1. CERMN UPRES EA 4258–FR CNRS 3038 INC3M, UFR des Sciences Pharmaceutiques–Universite de Caen Basse-Normandie, Bd Becquerel 14032 Caen Cedex, France., France
Abstract
The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anti-cancer agents. These compounds belong to the tripentone family and are based on 9H-pyrrolo[1,2-a]indol- 9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Pharmacology,Molecular Medicine
Cited by
21 articles.
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